The Win + Shift + S shortcut in Windows 10 lets you capture part or all of the screen and copy it to the clipboard. Most of the time, this OS feature works just as expected, but every now and then it can stop responding. If you are running into this problem, the following guide should help.
1. Clean the keys on your Windows 10 keyboard
Check whether anything is stuck under the Win, Shift and S keys, and physically clean the keys on your keyboard.
2. Turn on the Clipboard History toggle in Windows 10
Click the Start button and select Settings.
Select the System > Sound tile and scroll down to find the Clipboard option.
Click it, and in the right-hand pane, check whether the Clipboard History toggle is turned on.

If it isn't, flip the switch to the On position.
3. Check the Snip & Sketch toggle in Windows 10
Once again, open Settings, select the System tile and navigate to the Notifications & actions section.

Here, make sure the Snip & Sketch toggle is set to On.
4. Reset Snip & Sketch in Windows 10
If the methods above don't give you the result you want, try resetting Snip & Sketch. To do this, go to Settings > Apps > Apps & features. There, click Snip & Sketch.
You will see an Advanced options link appear below the entry. Click it, then hit the Reset button on the next screen.

Alternatively, you can uninstall the app and reinstall it from the Microsoft Store. Go to Settings > Apps > Apps & features and you will see an Uninstall button for Snip & Sketch. Go ahead and uninstall the app. Then head to the Microsoft Store and install it again.
5. Unplug and reconnect USB devices on Windows 10
Unplug and reconnect your USB devices, such as game controllers, and see whether that helps.
6. Use PrintScreen instead of Win + Shift + S on Windows 10
As an alternative, you can use the PrintScreen key in place of Win + Shift + S.
To do so, press Win + I to open Settings > Ease of Access > Keyboard, find the Locate Use the PrtScrn button to open screen snipping option, and turn the feature on.
7. Troubleshoot in a Clean Boot State on Windows 10
Third-party processes can also interfere with the Windows + Shift + S shortcut. To pinpoint the culprit, perform a Clean Boot and troubleshoot the problem manually.
Good luck fixing the issue!
